(E)-retinoic acid-4,4,18,18,18-d5

Base Information

Chemical Name:(E)-retinoic acid-4,4,18,18,18-d5
CAS No.:78996-15-3
Molecular Formula:C₂₀H₂₈O₂
Molecular Weight:305.401
Hs Code.:

Synonyms:(E)-retinoic acid-4,4,18,18,18-d5

Suppliers and Price of (E)-retinoic acid-4,4,18,18,18-d5

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
all-trans-RetinoicAcid-d5(major)
0.5mg
$ 145.00

Cayman Chemical
13-cis-Retinoic Acid-d5 ≥99% deuterated forms (d1-d5)
1mg
$ 395.00

AK Scientific
(2Z,4E,6E,8E)-9-[3,3-Dideuterio-6,6-dimethyl-2-(trideuteriomethyl)cyclohexen-1-yl]-3,7-dimethylnona-2,4,6,8-tetraenoicacid
1mg
$ 633.00

Total 6 raw suppliers

Chemical Property of (E)-retinoic acid-4,4,18,18,18-d5

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

all-trans-RetinoicAcid-d5(major) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description 13-cis Retinoic acid-d5 is intended for use as an internal standard for the quantification of 13-cis retinoic acid by GC- or LC-MS. 13-cis Retinoic acid is a naturally occurring retinoid that inhibits retinol oxidation and dehydrogenation of 17β-hydroxy steroids.

Technology Process of (E)-retinoic acid-4,4,18,18,18-d5

There total 7 articles about (E)-retinoic acid-4,4,18,18,18-d5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 78995-96-7
ethyl (E)-retinoate-4,4,18,18,18-d5

: 78996-15-3
(E)-retinoic acid-4,4,18,18,18-d5

Guidance literature:: With potassium hydroxide; In ethanol; at 80 ℃; for 0.2h;
DOI:10.1021/jm00142a018

Reference yield:

: 63826-41-5
2E,4E,6E-2,6-Dimethyl-7-ethoxycarbonyl-2,4,6-heptatrienal

: 78996-15-3
(E)-retinoic acid-4,4,18,18,18-d5

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, from -30 deg C to 0 deg C, 1 h, 2.) THF, hexane, a) RT, 17 h, b) 60 deg C, 1 h

2: 56 percent / aq. KOH / ethanol / 0.2 h / 80 °C

With potassium hydroxide; n-butyllithium; In ethanol;
DOI:10.1021/jm00142a018

Reference yield:

: 14505-74-9,41721-03-3,59462-59-8,432-24-6
α-cyclocitral

: 78996-15-3
(E)-retinoic acid-4,4,18,18,18-d5

Guidance literature:: Multi-step reaction with 6 steps

1: 4.7 g / MeOH-d, Na / 250 h

2: 1.) 9-borabicyclo<3.3.1>nonane (9-BBN), 2.) 2-aminoethanol / 1.) THF, RT, 24 h, 2.) ether, a) RT, 80 min, b) -5 deg C, 1.5 h

3: pyridine, PBr₃ / hexane; diethyl ether / 2.5 h / -15 - 20 °C

4: CH₂Cl₂ / 40 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, from -30 deg C to 0 deg C, 1 h, 2.) THF, hexane, a) RT, 17 h, b) 60 deg C, 1 h

6: 56 percent / aq. KOH / ethanol / 0.2 h / 80 °C

With pyridine; potassium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; deuteromethanol; sodium; phosphorus tribromide; ethanolamine; In diethyl ether; ethanol; hexane; dichloromethane;
DOI:10.1021/jm00142a018