N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide

Base Information

• Chemical Name: N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide
• CAS No.: 1431411-28-7
• Molecular Formula: C₂₄H₂₈N₆O₃S
• Molecular Weight: 480.591

Synonyms:N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide

Chemical Property of N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide

There total 9 articles about N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(4-(2-aminoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide + m-(ethylaminocarbonyl)benzoic acid (126926-33-8) → N1-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N3-ethylisophthalamide (1431411-28-7)

Guidance literature:

m-(ethylaminocarbonyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

4-(4-(2-aminoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 77.0%

4-(4-(2-aminoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide hydrochloride + m-(ethylaminocarbonyl)benzoic acid (126926-33-8) → N1-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N3-ethylisophthalamide (1431411-28-7)

Guidance literature:

m-(ethylaminocarbonyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

4-(4-(2-aminoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm400204k

Reference yield:

methyl 3-(ethylcarbamoyl)benzoate (126926-40-7) → N1-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N3-ethylisophthalamide (1431411-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / methanol; water / 72 h / 20 °C

1.2: pH 1 - 2

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h

With N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm400204k

upstream raw materials:

methyl 3-(ethylcarbamoyl)benzoate

m-(ethylaminocarbonyl)benzoic acid

4-chlorothieno[3,2-d]pyrimidine

4-chlorothieno[3,2-d]pyrimidine-6-carbonyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1431411-28-7 N¹-(2-(1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)-N³-ethylisophthalamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send