21-chloropregnenolone

Base Information

• Chemical Name: 21-chloropregnenolone
• CAS No.: 30459-98-4
• Molecular Formula: C21H31 Cl O2
• Molecular Weight: 350.929
• Mol file: 30459-98-4.mol

Synonyms:Pregn-5-en-20-one,21-chloro-3b-hydroxy- (8CI)

Chemical Property of 21-chloropregnenolone

Chemical Property:

• Vapor Pressure: 6.55E-11mmHg at 25°C
• Boiling Point: 472.4°Cat760mmHg
• PKA: 14.99±0.70(Predicted)
• Flash Point: 239.5°C
• PSA: 37.30000
• Density: 1.16g/cm³
• LogP: 4.73420

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 21-chloropregnenolone

There total 3 articles about 21-chloropregnenolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 21-chloro-3β-hydroxy-pregn-5-en-20-one (30459-98-4)

Guidance literature:

With hydrogenchloride; ethanol;

DOI:10.1002/hlca.193702001158

Reference yield:

21-diazo-3β-hydroxy-pregn-5-en-20-one (33769-71-0) → 21-chloro-3β-hydroxy-pregn-5-en-20-one (30459-98-4)

Guidance literature:

With hydrogenchloride; diethyl ether;

DOI:10.1002/hlca.193902201139

Reference yield:

20-(2-hydroxyethyl)iminopregn-5-en-3β-ol (30459-95-1) → 21-chloro-3β-hydroxy-pregn-5-en-20-one (30459-98-4)

Guidance literature:

Multistep reaction; (i) N-chloro-succinimide, Et₂O, (ii) aq. HCl;

DOI:10.1016/S0040-4020(01)98727-7

upstream raw materials:

21-diazo-3β-hydroxy-pregn-5-en-20-one

20-(2-hydroxyethyl)iminopregn-5-en-3β-ol

Downstream raw materials:

Progesterone

Pregnenolone