2-Chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Base Information

Chemical Name:2-Chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine
CAS No.:889673-50-1
Molecular Formula:C₁₆H₁₅ClN₄O
Molecular Weight:314.774
Hs Code.:
DSSTox Substance ID:DTXSID401199016

Synonyms:SCHEMBL13765749;2-Chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine;DTXSID401199016;889673-50-1

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:314.0934388
Heavy Atom Count:22
Complexity:379

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCOC(C1)N2C=NC3=C(N=C(N=C32)Cl)C4=CC=CC=C4

Technology Process of 2-Chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

There total 3 articles about 2-Chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 20419-68-5
2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 98-80-6
phenylboronic acid

: 889673-50-1
2-chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 150 ℃; for 0.333333h; microwave irradiation;
DOI:10.1021/jm050640i

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 889673-50-1
2-chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: pTSA / tetrahydrofuran

2: 71 percent / K₂CO₃; Pd(PPh₃)4 / toluene / 0.33 h / 150 °C / microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm050640i

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 889673-50-1
2-chloro-6-phenyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: pTSA / tetrahydrofuran

2: 71 percent / K₂CO₃; Pd(PPh₃)4 / toluene / 0.33 h / 150 °C / microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm050640i