C₂₂H₂₁ClF₂NO₃PS

Base Information

• Chemical Name: C₂₂H₂₁ClF₂NO₃PS
• CAS No.: 936366-48-2
• Molecular Formula: C₂₂H₂₁ClF₂NO₃PS
• Molecular Weight: 483.903
• Mol file: 936366-48-2.mol

Synonyms:C₂₂H₂₁ClF₂NO₃PS

Chemical Property of C₂₂H₂₁ClF₂NO₃PS

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₂₂H₂₁ClF₂NO₃PS

There total 4 articles about C₂₂H₂₁ClF₂NO₃PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H16ClO2PS (936366-25-5) + C9H5F2NO (936366-62-0) → C22H21ClF2NO3PS (936366-48-2)

Guidance literature:

C₁₃H₁₆ClO₂PS; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.75h;

C₉H₅F₂NO; In hexane; toluene; at -78 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm0700619

Reference yield:

3-(bromomethyl)-5-chloro-1-benzothiophene (1198-51-2) → C22H21ClF2NO3PS (936366-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 73 percent / 2.25 h / Heating

2.1: butyllithium / toluene; hexane / 0.75 h / -78 °C

2.2: toluene; hexane / 0.5 h / -78 °C

With n-butyllithium; In hexane; toluene;

DOI:10.1021/jm0700619

Reference yield:

(E)-3-(3,4-difluorophenyl)acrylic acid (112897-97-9) → C22H21ClF2NO3PS (936366-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; diphenylphosphoryl azide / benzene / 0 - 20 °C

2.1: toluene / 3 h / Heating

3.1: butyllithium / toluene; hexane / 0.75 h / -78 °C

3.2: toluene; hexane / 0.5 h / -78 °C

With n-butyllithium; diphenylphosphoranyl azide; triethylamine; In hexane; toluene; benzene;

DOI:10.1021/jm0700619

upstream raw materials:

C₁₃H₁₆ClO₂PS

C₉H₅F₂NO

3-(bromomethyl)-5-chloro-1-benzothiophene

(E)-3-(3,4-difluorophenyl)acrylic acid

Refernces