(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Base Information

Chemical Name:(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester
CAS No.:98664-95-0
Molecular Formula:C₂₈H₃₀N₂O₆S
Molecular Weight:522.622
Hs Code.:

(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Synonyms:(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

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Chemical Property of (1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

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Technology Process of (1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

There total 11 articles about (1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98664-94-9,98718-41-3
(1S,9S,9aR)-9-Isopropenyl-4-(toluene-4-sulfonyl)-2,3,4,8,9,9a-hexahydro-1H-indolo[2,3,4-def]isoquinoline-1-carboxylic acid ethyl ester

: 79-22-1
methyl chloroformate

: 98664-95-0
(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -20 - 20 ℃; for 1.25h;

Reference yield:

: 98665-02-2
(E)-2-(Formyl-methoxymethyl-amino)-3-[4-(3-oxo-butyl)-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

: 98664-95-0
(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / DBU / benzene / 6 h

2: 27 percent / DBU / benzene / 3.5 h

3: 2.) 50 percent NaH / 1.) THF, -80 deg C, 20 min, 2.) DMF, THF, from 0 deg C to RT, 1 h

4: 23 percent / 1 N HCl / dimethylsulfoxide; ethanol; H₂O / 2 h / Heating

5: 89 percent / Et₃N / CH₂Cl₂ / 1.25 h / -20 - 20 °C

With hydrogenchloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;

Reference yield:

: 98665-03-3
(Z)-2-(Formyl-methoxymethyl-amino)-3-[4-(3-oxo-butyl)-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

: 98664-95-0
(1R,9R,9aS)-9-Isopropenyl-4-(toluene-4-sulfonyl)-1,3,4,8,9,9a-hexahydro-indolo[2,3,4-def]isoquinoline-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / DBU / benzene / 6 h

2: 27 percent / DBU / benzene / 3.5 h

3: 2.) 50 percent NaH / 1.) THF, -80 deg C, 20 min, 2.) DMF, THF, from 0 deg C to RT, 1 h

4: 23 percent / 1 N HCl / dimethylsulfoxide; ethanol; H₂O / 2 h / Heating

5: 89 percent / Et₃N / CH₂Cl₂ / 1.25 h / -20 - 20 °C

With hydrogenchloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;