1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

Base Information

Chemical Name:1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine
CAS No.:155308-58-0
Molecular Formula:C₂₄H₂₉Cl₂NO₃
Molecular Weight:450.405
Hs Code.:

Synonyms:1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

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Chemical Property of 1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

Chemical Property:

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Technology Process of 1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

There total 1 articles about 1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178371-54-5,146396-08-9
3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

: 146031-94-9
α-(3-isopropoxyphenyl)acetic acid

: 155308-58-0
1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

Guidance literature:: With hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium chloride; In dichloromethane;

Reference yield:

: 155308-58-0
1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

: C₃₈H₄₄Cl₂N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: Et₃N / dimethylformamide / 70 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00260-1

Reference yield:

: 155308-58-0
1-(3-isopropoxy-phenyl-acetyl)-3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-piperidine

: 1'-(2-{3-(3,4-Dichloro-phenyl)-1-[2-(3-isopropoxy-phenyl)-acetyl]-piperidin-3-yl}-ethyl)-4H-spiro[isoquinoline-1,4'-piperidin]-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: Et₃N / dimethylformamide / 70 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00260-1