Fosphenytoin

Base Information

Chemical Name:Fosphenytoin
CAS No.:93390-81-9
Molecular Formula:C16H15N2O6P
Molecular Weight:362.279
Hs Code.:2933990090
UNII:B4SF212641
DSSTox Substance ID:DTXSID9044299
Nikkaji Number:J540.502E
Wikipedia:Fosphenytoin
Wikidata:Q5473363
NCI Thesaurus Code:C65766
Pharos Ligand ID:LJG6SS696FQC
Metabolomics Workbench ID:43491
ChEMBL ID:CHEMBL1201336
Mol file:93390-81-9.mol

Synonyms:3-(hydroxymethyl)phenytoin disodium phosphate;3-(hydroxymethyl)phenytoin phosphate ester;ACC 9653;ACC-9653;Cerebyx;fosphenytoin;fosphenytoin sodium;fosphenytoin, disodium salt;HMPDP;Prodilantin

Suppliers and Price of Fosphenytoin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of Fosphenytoin

Chemical Property:

Melting Point:173-176.5°
PKA:1.74±0.10(Predicted)
PSA：125.98000
Density:1.495g/cm³
LogP:1.81550
XLogP3:0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:362.06677320
Heavy Atom Count:25
Complexity:547

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Anticonvulsants
Canonical SMILES:C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)(O)O)C3=CC=CC=C3
Recent ClinicalTrials:Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 20 Patients
Recent EU Clinical Trials:“FAST ACUTE SEDATION AT INTENSIVE CARE VS. HIGH-DOSE I.V. ANTI-SEIZURE MEDICATION FOR TREATMENT OF NON-CONVULSIVE STATUS EPILEPTICUS - A RANDOMIZED, MULTICENTER TRIAL (FAST TRIAL)”
Recent NIPH Clinical Trials:Efficacy and safety of levetiracetam therapy for early postoperative seizures following brain tumor surgery
Description Cerebyx was launched for the treatment of status epilepticus and for neurosurgery derived seizures. Fosphenytoin is rapidly converted by phosphatases to phenytoin. Caffeine Citrate is readily water soluble thus overcoming an important problem associated with Dilantin.

Technology Process of Fosphenytoin

There total 5 articles about Fosphenytoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.5%

: 93360-08-8
phosphoric acid dibenzyl ester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl ester

: 93390-81-9
fosphenytoin

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 0.416667h; under 3102.9 Torr;
DOI:10.1002/jps.2600730812

Reference yield:

: 57-41-0
phenythoin

: 93390-81-9
fosphenytoin

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / potassium carbonate / H₂O / 24 h / Ambient temperature

2: 61 percent / phosphorous trichloride / CH₂Cl₂ / 24 h / Ambient temperature

3: 67 percent / benzene / 2 h / Heating

4: 54.5 percent / H₂ / palladium on activated carbon / ethyl acetate / 0.42 h / 3102.9 Torr

With hydrogen; potassium carbonate; phosphorus trichloride; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; benzene;
DOI:10.1002/jps.2600730812

Reference yield:

: 93360-07-7
3-(chloromethyl)-5,5-diphenylhydantoin

: 93390-81-9
fosphenytoin

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / benzene / 2 h / Heating

2: 54.5 percent / H₂ / palladium on activated carbon / ethyl acetate / 0.42 h / 3102.9 Torr

With hydrogen; palladium on activated charcoal; In ethyl acetate; benzene;
DOI:10.1002/jps.2600730812