(2S,4S)-4-hydroxypyrrolidinium-2-carboxylate

Base Information

Chemical Name:(2S,4S)-4-hydroxypyrrolidinium-2-carboxylate
CAS No.:618-27-9
Molecular Formula:C5H9NO3
Molecular Weight:131.131
Hs Code.:29339900
Mol file:618-27-9.mol

Synonyms:CIS-L-4-HYDROXYPROLINE;cis-oxyproline;cis-hydroxy-L-proline;cis-L-4-hydroxy-proline;CHEBI:63727;cis-4-hydroxy-L-proline zwitterion;(2S,4S)-4-hydroxypyrrolidinium-2-carboxylate

Suppliers and Price of (2S,4S)-4-hydroxypyrrolidinium-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
cis-4-Hydroxy-L-proline
100mg
$ 496.00

Usbiological
cis-4-Hydroxy-L-proline
1g
$ 312.00

TRC
cis-4-Hydroxy-L-proline
50mg
$ 65.00

TCI Chemical
cis-4-Hydroxy-L-proline >97.0%(T)
1g
$ 270.00

TCI Chemical
cis-4-Hydroxy-L-proline >97.0%(T)
100mg
$ 55.00

SynQuest Laboratories
cis-4-Hydroxy-L-proline 97%
25 g
$ 813.00

Sigma-Aldrich
cis-4-Hydroxy-L-proline collagen synthesis inhibitor
1g
$ 856.00

Sigma-Aldrich
cis-4-Hydroxy-L-proline collagen synthesis inhibitor
50mg
$ 64.90

Sigma-Aldrich
cis-4-Hydroxy-L-proline collagen synthesis inhibitor
250mg
$ 258.00

Medical Isotopes, Inc.
cis-4-Hydroxy-L-proline-2,5,5-d3
10 mg
$ 290.00

Total 124 raw suppliers

Chemical Property of (2S,4S)-4-hydroxypyrrolidinium-2-carboxylate

Chemical Property:

Appearance/Colour:White to beige powder
Melting Point:257 ºC (dec.)(lit.)
Refractive Index:-59 ° (C=2, H2O)
Boiling Point:355.2 ºC at 760 mmHg
PKA:2.14±0.40(Predicted)
Flash Point:168.6 ºC
PSA：69.56000
Density:1.395 g/cm³
LogP:-0.87740
Storage Temp.:Store at RT.
Solubility.:soluble
Water Solubility.:soluble
XLogP3:-2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:131.058243149
Heavy Atom Count:9
Complexity:120

Purity/Quality:

99%, ^*data from raw suppliers

cis-4-Hydroxy-L-proline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 24/25-36/37/39-27-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1C(C[NH2+]C1C(=O)[O-])O
Isomeric SMILES:C1[C@@H](C[NH2+][C@@H]1C(=O)[O-])O
Uses Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs. cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.

Technology Process of (2S,4S)-4-hydroxypyrrolidinium-2-carboxylate

There total 53 articles about (2S,4S)-4-hydroxypyrrolidinium-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 618-27-9,30724-02-8
hydroxy L-proline

Guidance literature:: With ferrous(II) sulfate heptahydrate; cis-4-proline hydroxylase; sodium L-ascorbate; at 25 ℃; for 16h; stereospecific reaction;
DOI:10.3762/bjoc.7.193