(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Base Information

Chemical Name:(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid
CAS No.:1190614-98-2
Molecular Formula:C₁₈H₂₆ClNO₃Si
Molecular Weight:367.948
Hs Code.:
Mol file:1190614-98-2.mol

Synonyms:(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Suppliers and Price of (R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Chemical Property:

Boiling Point:464.2±45.0 °C(Predicted)
PKA:3.86±0.10(Predicted)
Density:1.112±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of (R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

There total 7 articles about (R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1190614-97-1
(S)-4-benzyl-3-((R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoyl)oxazolidin-2-one

: 1190614-98-2
(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Guidance literature:: With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1021/jm4017224

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 1190614-98-2
(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; pivaloyl chloride / tetrahydrofuran / 2.33 h / -25 °C / Inert atmosphere

1.2: 12 h / -25 - 20 °C

2.1: triethylamine; magnesium chloride / ethyl acetate / 72 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; methanol / 5 h / 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 3 °C / Inert atmosphere

5.1: sodium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 18 h / 0 - 5 °C / Inert atmosphere

5.2: 0 °C / pH 3

With 2,6-dimethylpyridine; methanol; water; dihydrogen peroxide; pivaloyl chloride; triethylamine; trifluoroacetic acid; sodium hydroxide; magnesium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1190614-96-0
(S)-4-benzyl-3-((R)-2-((S)-(6-chloropyridin-3-yl)(hydroxy)methyl)hex-5-ynoyl)oxazolidin-2-one

: 1190614-98-2
(R)-2-((S)-(6-chloropyridin-3-yl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 3 °C / Inert atmosphere

2.1: sodium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 18 h / 0 - 5 °C / Inert atmosphere

2.2: 0 °C / pH 3

With 2,6-dimethylpyridine; water; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane;