Technology Process of C18H22O3
There total 5 articles about C18H22O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H20O;
With
n-butyllithium;
at -78 ℃;
for 1h;
methyl chloroformate;
at -78 - 20 ℃;
for 15h;
With
sodium hydrogencarbonate;
In
water;
DOI:10.1021/ol102989q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 0.17 h / 20 °C / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / hexane; dichloromethane / -78 °C / Inert atmosphere
3.1: diethyl ether / -78 - 20 °C
3.2: -20 °C
4.1: n-butyllithium / 1 h / -78 °C
4.2: 15 h / -78 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; diisobutylaluminium hydride; triethylamine;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol102989q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; sodium iodide / 3 h / 115 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 0.17 h / 20 °C / Inert atmosphere
2.2: 3 h / 20 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / hexane; dichloromethane / -78 °C / Inert atmosphere
4.1: diethyl ether / -78 - 20 °C
4.2: -20 °C
5.1: n-butyllithium / 1 h / -78 °C
5.2: 15 h / -78 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; diisobutylaluminium hydride; acetic acid; triethylamine; sodium iodide;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol102989q
