4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid

Base Information

• Chemical Name: 4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid
• CAS No.: 330455-22-6
• Molecular Formula: C₂₀H₂₈N₂O₃Si
• Molecular Weight: 372.539
• Mol file: 330455-22-6.mol

Synonyms:4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid

Chemical Property of 4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid

Chemical Property:

Purity/Quality:

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Technology Process of 4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid

There total 1 articles about 4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

cinchomeronic anhydride (4664-08-8) + N-triisopropylsilylpyrrole (87630-35-1) → 4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid (330455-22-6)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.3987/COM-98-8401

Reference yield:

4-(1-triisopropylsilanyl-1H-pyrrole-3-carbonyl)-nicotinic acid (330455-22-6) → methyl 4-[[1-phenylsulfonyl-1H-3-pyrrolyl]carbonyl]nicotinate

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / methanol; diethyl ether / 20 °C

2: tetrabutylammonium fluoride / tetrahydrofuran; acetonitrile / 0.08 h

3: 75 percent / tetrabutyl ammoniumsulfate; aq. NaOH / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; tetrabutyl ammonium fluoride; tetrabutylammonium sulfate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;

DOI:10.3987/COM-98-8401

upstream raw materials:

cinchomeronic anhydride

N-triisopropylsilylpyrrole