6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate

Base Information

• Chemical Name: 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate
• CAS No.: 85932-30-5
• Molecular Formula: C₂₀H₂₄O₄S
• Molecular Weight: 360.474
• Mol file: 85932-30-5.mol

Synonyms:6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate

Chemical Property of 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate

There total 3 articles about 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinol (85932-29-2) + p-toluenesulfonyl chloride (98-59-9) → 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate (85932-30-5)

Guidance literature:

With pyridine; In benzene; at 0 ℃; for 9h;

DOI:10.1016/0040-4020(82)80115-4

Reference yield:

6-methoxy-2-methyl-1,2,3,4-tetrahydro-2-naphthoic acid (38840-93-6) → 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate (85932-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.7 g / conc. H₂SO₄ / 6 h / Heating

2: 86 percent / sodium dihydrobismethoxyethoxy aluminate / benzene / 2 h

3: 90 percent / pyridine / benzene / 9 h / 0 °C

With pyridine; sodium bis(2-methoxyethoxy)aluminium dihydride; sulfuric acid; In benzene;

DOI:10.1016/0040-4020(82)80115-4

Reference yield:

methyl-6-methoxy-2-methyl-1,2,3,4-tetrahydro-2-naphthoate (85932-28-1) → 6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinyl tosylate (85932-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / sodium dihydrobismethoxyethoxy aluminate / benzene / 2 h

2: 90 percent / pyridine / benzene / 9 h / 0 °C

With pyridine; sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene;

DOI:10.1016/0040-4020(82)80115-4

upstream raw materials:

6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthyl-2-carbinol

p-toluenesulfonyl chloride

6-methoxy-2-methyl-1,2,3,4-tetrahydro-2-naphthoic acid

methyl-6-methoxy-2-methyl-1,2,3,4-tetrahydro-2-naphthoate