3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

Base Information

Chemical Name:3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide
CAS No.:324002-10-0
Molecular Formula:C₃₆H₃₈N₄O₃
Molecular Weight:574.723
Hs Code.:

Synonyms:3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

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Technology Process of 3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

There total 4 articles about 3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 2696-84-6
4-propylaniline

: 324002-09-7
3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-carboxylic acid

: 324002-10-0
3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1002/jhet.5570370513

Reference yield:

: 16732-57-3
5-nitro-indole-2-carboxylic acid ethyl ester

: 324002-10-0
3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / MeSO₃H / CH₂Cl₂; CHCl₃ / 18 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h

2.2: 70 percent / dimethylformamide / 3 h / 80 °C

3.1: 93 percent / 2 N aq. NaOH / ethanol / 4 h / Heating

4.1: 51 percent / N,n-diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 18 h / 20 °C

With sodium hydroxide; methanesulfonic acid; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Condensation / 2.1: Metallation / 2.2: Substitution / 3.1: saponification / 4.1: Condensation;
DOI:10.1002/jhet.5570370513

Reference yield:

: 324002-07-5
ethyl 3-benzhydryl-5-nitro-1H-indole-2-carboxylate

: 324002-10-0
3-benzhydryl-1-(3-dimethylamino-propyl)-5-nitro-1H-indole-2-(4-propyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 70 percent / dimethylformamide / 3 h / 80 °C

2.1: 93 percent / 2 N aq. NaOH / ethanol / 4 h / Heating

3.1: 51 percent / N,n-diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 18 h / 20 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Substitution / 2.1: saponification / 3.1: Condensation;
DOI:10.1002/jhet.5570370513