4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

Base Information

Chemical Name:4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine
CAS No.:1443114-35-9
Molecular Formula:C₂₂H₁₇F₂N₃O₂S
Molecular Weight:425.459
Hs Code.:

Synonyms:4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

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Chemical Property of 4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

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Technology Process of 4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

There total 5 articles about 4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1443114-33-7
5-bromo-2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazole

: 1692-15-5
4-pyridylboronic acid

: 1443114-35-9
4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; at 120 ℃; for 8h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ml400166b

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1443114-35-9
4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: dihydrogen peroxide / acetic acid / 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / tetrachloromethane / 0 °C / Inert atmosphere; Reflux

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water / 8 h / 120 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; sodium carbonate; caesium carbonate; In tetrahydrofuran; tetrachloromethane; water; acetic acid; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/ml400166b

Reference yield:

: 1015445-75-6
4-(4-fluorophenyl)-1-methyl-1H-imidazole-2-thiol

: 1443114-35-9
4-(2-((4-fluorobenzyl)sulfonyl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-5-yl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: dihydrogen peroxide / acetic acid / 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / tetrachloromethane / 0 °C / Inert atmosphere; Reflux

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water / 8 h / 120 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; sodium carbonate; caesium carbonate; In tetrahydrofuran; tetrachloromethane; water; acetic acid; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/ml400166b