N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

Base Information

Chemical Name:N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate
CAS No.:1439876-77-3
Molecular Formula:CH₄O₃S*C₂₉H₂₃F₃N₄O₅
Molecular Weight:660.628
Hs Code.:

N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

Synonyms:N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

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Chemical Property of N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

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Technology Process of N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

There total 13 articles about N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1439876-76-2
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 1439876-77-3
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

Guidance literature:: In acetonitrile; at 80 ℃;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1439876-77-3
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 15 - 25 °C

1.2: 1.17 h

2.1: hydrogen / methanol / 4 h / 517.16 - 1034.32 Torr

3.1: triethylamine / tetrahydrofuran / 15 - 25 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

5.1: acetonitrile / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; potassium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 35260-93-6,932750-29-3
ethyl 2-cyano-3-ethoxybut-2-enoate

: 1439876-77-3
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 70 °C

2: acetic acid / Reflux

3: copper diacetate; pyridine / dichloromethane / 4 h / 15 - 25 °C

4: lithium hydroxide; water / ethanol / 16 h / 15 - 25 °C

5: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

6: triethylamine / tetrahydrofuran / 15 - 25 °C

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

8: acetonitrile / 80 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; water; copper diacetate; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene; acetonitrile;