2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Base Information

• Chemical Name: 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate
• CAS No.: 134969-22-5
• Molecular Formula: C₃₂H₃₀F₃N₃O₂S
• Molecular Weight: 577.67

Synonyms:2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Chemical Property of 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Chemical Property:

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Technology Process of 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

There total 6 articles about 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) → 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate (134969-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 24 h / Heating

2: 3.0 g / LiOH / ethanol / 16 h / Ambient temperature

3: 1.) 1,1-carbonyldiimidazole (CDI) / 1.) THF, 23 deg C, 1 h, 2.) 120 deg C, 0.5 h

With lithium hydroxide; 1,1'-carbonyldiimidazole; In ethanol;

DOI:10.1021/jm00111a047

Reference yield:

ethyl 4-(phenylthio)-acetoacetate (25907-38-4) → 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate (134969-22-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / 48 h / 120 °C

2: ethanol / 24 h / Heating

3: 3.0 g / LiOH / ethanol / 16 h / Ambient temperature

4: 1.) 1,1-carbonyldiimidazole (CDI) / 1.) THF, 23 deg C, 1 h, 2.) 120 deg C, 0.5 h

With lithium hydroxide; 1,1'-carbonyldiimidazole; In ethanol;

DOI:10.1021/jm00111a047

Reference yield:

2-cyanoethyl 3-oxo-4-(phenylthio)butanoate (134969-40-7) → 2-ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate (134969-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 24 h / Heating

2: 3.0 g / LiOH / ethanol / 16 h / Ambient temperature

3: 1.) 1,1-carbonyldiimidazole (CDI) / 1.) THF, 23 deg C, 1 h, 2.) 120 deg C, 0.5 h

With lithium hydroxide; 1,1'-carbonyldiimidazole; In ethanol;

DOI:10.1021/jm00111a047

upstream raw materials:

2-(N-benzyl-N-methyl)amino-1-ethanol

5-Cyano-6-methyl-2-phenylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid

2-Trifluoromethylbenzaldehyde

ethyl 4-(phenylthio)-acetoacetate

Downstream raw materials:

2-Benzenesulfinylmethyl-5-cyano-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester

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