5-CYANOTRYPTAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 5-CYANOTRYPTAMINE HYDROCHLORIDE
• CAS No.: 101831-71-4
• Molecular Formula: C₁₁H₁₁N₃*ClH
• Molecular Weight: 221.689
• Hs Code.: 2933990090
• Mol file: 101831-71-4.mol

Synonyms:1H-Indole-5-carbonitrile,3-(2-aminoethyl)-, monohydrochloride (9CI); 3-(2-Aminoethyl)-5-cyano-1H-indolehydrochloride

Chemical Property of 5-CYANOTRYPTAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.21E-07mmHg at 25°C
• Boiling Point: 423.6°C at 760 mmHg
• Flash Point: 210°C
• PSA: 65.60000
• LogP: 3.04308
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Aminoethyl)-1H-indole-5-carbonitrilehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CYANOTRYPTAMINE HYDROCHLORIDE

There total 2 articles about 5-CYANOTRYPTAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-chlorobutanal dimethyl acetal (29882-07-3) + 4-hydrazinobenzonitrile hydrochloride (2863-98-1) → 3-(2-aminoethyl)-5-cyano-1H-indole hydrochloride (101831-71-4)

Guidance literature:

In ethanol; water; for 18h; Heating;

DOI:10.1021/jm00045a006

Reference yield:

4-Aminobenzonitrile (873-74-5) → 3-(2-aminoethyl)-5-cyano-1H-indole hydrochloride (101831-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. HCl, NaNO₂, 2.) SnCl₂*2H₂O, aq. HCl / 2.) 15 min

2: 35 percent / ethanol; H₂O / 18 h / Heating

With hydrogenchloride; tin(ll) chloride; sodium nitrite; In ethanol; water;

DOI:10.1021/jm00045a006

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-(2-aminoethyl)-5-cyano-1H-indole hydrochloride (101831-71-4) → 3-<2-amino>ethyl>-5-cyano-1H-indole (144035-34-7)

Guidance literature:

With triethylamine; In dichloromethane; 1.) -10 deg C, 30 min, 2.) RT, 3 h;

DOI:10.1021/jm00045a006

upstream raw materials:

4-chlorobutanal dimethyl acetal

4-hydrazinobenzonitrile hydrochloride

4-Aminobenzonitrile

Downstream raw materials:

3-<2-amino>ethyl>-5-cyano-1H-indole

N,N-dimethyl 2-(5-cyano-1H-indol-3-yl)ethylamine

Refernces