phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose

Base Information

• Chemical Name: phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose
• CAS No.: 1427066-83-8
• Molecular Formula: C₄₀H₃₂F₄O₇S
• Molecular Weight: 732.749
• Mol file: 1427066-83-8.mol

Synonyms:phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose

Chemical Property of phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose

There total 1 articles about phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,5-difluorobenzoyl chloride (35730-09-7) + phenyl-3,4-di-O-benzyl-α-D-thiomannopyranose → phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose (1427066-83-8)

Guidance literature:

With pyridine; at 20 ℃; for 4h;

DOI:10.1021/ja401385v

Reference yield: 87.0%

benzyl 3,4,6-tri-O-benzyl-2-O-(2,5-difluorobenzoyl)-α-D-mannopyranosyl-(1→3)-2,4-di-O-benzyl-β-D-mannopyranosyl-(1→4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1→4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside + phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose (1427066-83-8) → benzyl [3,4,6-tri-O-benzyl-2-O-(2,5-difluorobenzoyl)-α-D-mannopyranosyl-(1→3)]-[3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-mannopyranosyl-(1→6)]-2,4-di-O-benzyl-β-D-mannopyranosyl-(1→4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1→4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:

benzyl 3,4,6-tri-O-benzyl-2-O-(2,5-difluorobenzoyl)-α-D-mannopyranosyl-(1→3)-2,4-di-O-benzyl-β-D-mannopyranosyl-(1→4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1→4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside; phenyl-3,4-di-O-benzyl-2,6-di-O-(2,5-difluorobenzoyl)-α-D-thiomannopyranose; In dichloromethane; at 20 ℃; for 1h; Molecular sieve;

With N-iodo-succinimide; silver trifluoromethanesulfonate; In dichloromethane; at -10 ℃; for 2h;

DOI:10.1021/ja401385v

upstream raw materials:

2,5-difluorobenzoyl chloride