(S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 514214-66-5
• Molecular Formula: C₂₀H₂₂N₄O₃
• Molecular Weight: 366.42
• Mol file: 514214-66-5.mol

Synonyms:(S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 3 articles about (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate (514214-66-5)

Guidance literature:

N-tert-butoxycarbonyl-L-phenylalanine; With dicyclohexyl-carbodiimide; In dichloromethane; for 0.5h; Inert atmosphere;

1,2,3-Benzotriazole; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c3cc39291k

Reference yield: 59.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + 1-(methanesulfonyl)-1H-1,2,3-benzotriazole (37073-15-7) → (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate (514214-66-5)

Guidance literature:

With triethylamine; at 70 ℃; Microwave irradiation;

DOI:10.1039/c2ob26439k

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + ((S)-1-Chlorocarbonyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (462101-51-5) → (S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate (514214-66-5)

Guidance literature:

DOI:10.3184/030823407X272985

upstream raw materials:

1,2,3-Benzotriazole

((S)-1-Chlorocarbonyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

N-tert-butoxycarbonyl-L-phenylalanine

1-(methanesulfonyl)-1H-1,2,3-benzotriazole

Downstream raw materials:

N-tert-butyloxycarbonyl-L-phenylalanyl-L-alanine

(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyloxy)-4-methyl-pentanoic acid

(6S,9S,12S,14aS,20S,23S,25aS)-20-benzyl-6,12-di((S)-sec-butyl)-9-(hydroxymethyl)-23-isobutylhexadecahydro-1H-dipyrrolo[1,2-a:1',2'-j][1,4,7,10,13,16,19]heptaazacyclohenicosine-5,8,11,14,19,22,25(25aH)heptaone