(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Base Information

Chemical Name:(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester
CAS No.:197233-36-6
Molecular Formula:C₅₃H₇₅NO₅SSi₂
Molecular Weight:894.419
Hs Code.:

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Synonyms:(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

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Chemical Property of (3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

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Technology Process of (3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

There total 19 articles about (3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 188259-62-3
(1S)-[(1E)-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethynyl]-3-butenyl acetate

: 197233-34-4
(3R,4R,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,2,4,6,10-pentamethyl-3-triphenylsilanyloxy-undec-10-enal

: 197233-36-6
(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

: 197233-35-5
(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.666667h;
DOI:10.1021/ja971946k

Reference yield:

: 20949-84-2
2-methylthiazole-4-carbaldehyde

: 197233-36-6
(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / benzene / Heating

2: 60 percent / (S)-(-)-1,1'-bi-2-naphthol; Ti(O-i-Pr)4; 4 Angstroem sieves / CH₂Cl₂ / 70 h / -78 - -20 °C

3: 96 percent / 4-DMAP; Et₃N / CH₂Cl₂ / 2 h

4: 35 percent / LDA / tetrahydrofuran / 0.67 h / -78 °C

With titanium(IV) isopropylate; dmap; 4 A molecular sieve; (S)-[1,1']-binaphthalenyl-2,2'-diol; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; benzene; 1: Wittig reaction / 2: Addition / 3: Acetylation / 4: Addition;
DOI:10.1021/ja971946k

Reference yield:

: 184246-38-6
(E)-2-methyl-3-(2-methylthiazol-4-yl)acrylaldehyde

: 197233-36-6
(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / (S)-(-)-1,1'-bi-2-naphthol; Ti(O-i-Pr)4; 4 Angstroem sieves / CH₂Cl₂ / 70 h / -78 - -20 °C

2: 96 percent / 4-DMAP; Et₃N / CH₂Cl₂ / 2 h

3: 35 percent / LDA / tetrahydrofuran / 0.67 h / -78 °C

With titanium(IV) isopropylate; dmap; 4 A molecular sieve; (S)-[1,1']-binaphthalenyl-2,2'-diol; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Acetylation / 3: Addition;
DOI:10.1021/ja971946k