2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester

Base Information

• Chemical Name: 2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester
• CAS No.: 851527-15-6
• Molecular Formula: C₁₈H₂₄N₂O₄
• Molecular Weight: 332.4
• Mol file: 851527-15-6.mol

Synonyms:2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester

Chemical Property of 2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester

There total 2 articles about 2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2,6-diazabicylo[3.2.0]heptane-2-carboxylic acid tert-butyl ester (370880-27-6,1204405-68-4) + benzyl chloroformate (501-53-1,94274-21-2) → 2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester (851527-15-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 3h;

Reference yield: 48.0%

C19H28N2O7S (1204405-71-9) → 2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester (851527-15-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1016/j.tetlet.2009.10.028

Reference yield: 72.0%

2,6-diaza-bicyclo[3.2.0.]heptane-2,6-dicarboxylic acid 6-benzyl ester 2-tert-butyl ester (851527-15-6) → (2R,5R)-2,6-diaza-bicyclo[3.2.0]heptane-6-carboxylic acid benzyl ester (851527-17-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

2,6-diazabicylo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

benzyl chloroformate

C₁₉H₂₈N₂O₇S

Downstream raw materials:

(2R,5R)-2,6-diaza-bicyclo[3.2.0]heptane-6-carboxylic acid benzyl ester