3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Base Information

Chemical Name:3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide
CAS No.:777865-65-3
Molecular Formula:C₂₂H₂₉N₃O₂S₂
Molecular Weight:431.623
Hs Code.:

Synonyms:3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

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Chemical Property of 3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

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Technology Process of 3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

There total 3 articles about 3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 288-32-4
1H-imidazole

: 777865-63-1
3-(4-bromophenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

: 777865-65-3
3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Guidance literature:: With copper(l) iodide; caesium carbonate; rac-diaminocyclohexane; In N,N-dimethyl-formamide; at 180 ℃; for 0.666667h; microwave irradiation;
DOI:10.1021/jm049715t

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 777865-65-3
3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aq. K₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 3 h / Heating

2: 27 percent / CuI; 1,2-diaminocyclohexane; Cs₂CO₃ / dimethylformamide / 0.67 h / 180 °C / microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; rac-diaminocyclohexane; In ethanol; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling / 2: Ullman coupling;
DOI:10.1021/jm049715t

Reference yield:

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 777865-65-3
3-(4-imidazol-1-ylphenylmethyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aq. K₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 3 h / Heating

2: 27 percent / CuI; 1,2-diaminocyclohexane; Cs₂CO₃ / dimethylformamide / 0.67 h / 180 °C / microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; rac-diaminocyclohexane; In ethanol; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling / 2: Ullman coupling;
DOI:10.1021/jm049715t