(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid

Base Information

• Chemical Name: (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid
• CAS No.: 870839-41-1
• Molecular Formula: C₁₄H₁₄N₂O₃
• Molecular Weight: 258.277
• Mol file: 870839-41-1.mol

Synonyms:(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid

Chemical Property of (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid

There total 11 articles about (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (870837-18-6) + diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) → (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid (870839-41-1)

Guidance literature:

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde; diethoxyphosphoryl-acetic acid ethyl ester; With lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 9h;

With sodium hydroxide; water; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;

With hydrogenchloride; water; In tetrahydrofuran; ethanol; at 0 ℃;

Reference yield:

(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid sodium salt → (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid (870839-41-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 0 ℃; Acidic aqueous solution;

Reference yield:

diethylphosphonoacetic acid (3095-95-2) + 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (870837-18-6) → (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid (870839-41-1)

Guidance literature:

diethylphosphonoacetic acid; 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde; With lithium hydroxide; In tetrahydrofuran;

With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;

upstream raw materials:

diethylphosphonoacetic acid

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

diethoxyphosphoryl-acetic acid ethyl ester

4-formylamino-3-methoxybenzoic acid methyl ester

Downstream raw materials:

2-(4-fluorophenyl)-2-oxoethyl (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylate

1-benzyl-3-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}urea

tert-butyl N'-{(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acryloyl}hydrazinecarboxylate

(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-N-[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]acrylamide