ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

Base Information

Chemical Name:ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate
CAS No.:365462-46-0
Molecular Formula:C₃₁H₃₆N₄O₆
Molecular Weight:560.65
Hs Code.:

Synonyms:ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

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Chemical Property of ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

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Technology Process of ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

There total 7 articles about ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-benzyl-4-[4-({2-(2-ethoxy-2-oxoethoxy)-6-[(4-methoxybenzoyl)amino]phenyl}carbamoyl)phenyl]-1-methyl-1,4-diazepan-1-ium

: 365462-46-0
ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In acetic acid; at 20 ℃; for 3h; under 2204.15 Torr;
DOI:10.1021/jm200868m

Reference yield:

: 365462-76-6
N-(2-hydroxy-6-nitrophenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamide

: 365462-46-0
ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 30 °C / 760.05 Torr

2: pyridine / 72 h / 20 °C

3: methanol; chloroform / 22 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

5: palladium 10% on activated carbon; hydrogen / acetic acid / 3 h / 20 °C / 2204.15 Torr

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; chloroform; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm200868m

Reference yield:

: 365462-75-5
2-amino-3-nitrophenyl 4-(4-methyl-1,4-diazepan-1-yl)benzoate hydrochloride

: 365462-46-0
ethyl (3-[(4-methoxybenzoyl)amino]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / acetonitrile / 6 h / 70 °C

1.2: 14 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 30 °C / 760.05 Torr

3.1: pyridine / 72 h / 20 °C

4.1: methanol; chloroform / 22 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

6.1: palladium 10% on activated carbon; hydrogen / acetic acid / 3 h / 20 °C / 2204.15 Torr

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; chloroform; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200868m