Technology Process of 4-{2-[((E)-Buta-1,3-dienyl)-methoxycarbonyl-amino]-phenyl}-2,3-dihydro-pyrrole-1-carboxylic acid methyl ester
There total 8 articles about 4-{2-[((E)-Buta-1,3-dienyl)-methoxycarbonyl-amino]-phenyl}-2,3-dihydro-pyrrole-1-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 50percent NaOH, nBu4NBr / acetonitrile / Ambient temperature
2: 1.) DIBAL-H, 2.) H3O+ / 1.) toluene, -78 deg C
3: MgSO4 / diethyl ether
4: Me3SiCl, NaI / dimethylformamide / 3 h / 60 °C
5: 90 percent / acetone / 8 h / Ambient temperature
6: 95 percent / HCO2NH4 / 10percent Pd/C / methanol / Ambient temperature
7: toluene
8: proton sponge / toluene / 8 h / 0 - 20 °C
With
sodium hydroxide; chloro-trimethyl-silane; Proton Sponge; oxonium; tetrabutylammomium bromide; ammonium formate; diisobutylaluminium hydride; magnesium sulfate; sodium iodide;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/ja00060a083
- Guidance literature:
-
Multi-step reaction with 6 steps
1: MgSO4 / diethyl ether
2: Me3SiCl, NaI / dimethylformamide / 3 h / 60 °C
3: 90 percent / acetone / 8 h / Ambient temperature
4: 95 percent / HCO2NH4 / 10percent Pd/C / methanol / Ambient temperature
5: toluene
6: proton sponge / toluene / 8 h / 0 - 20 °C
With
chloro-trimethyl-silane; Proton Sponge; ammonium formate; magnesium sulfate; sodium iodide;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja00060a083
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) DIBAL-H, 2.) H3O+ / 1.) toluene, -78 deg C
2: MgSO4 / diethyl ether
3: Me3SiCl, NaI / dimethylformamide / 3 h / 60 °C
4: 90 percent / acetone / 8 h / Ambient temperature
5: 95 percent / HCO2NH4 / 10percent Pd/C / methanol / Ambient temperature
6: toluene
7: proton sponge / toluene / 8 h / 0 - 20 °C
With
chloro-trimethyl-silane; Proton Sponge; oxonium; ammonium formate; diisobutylaluminium hydride; magnesium sulfate; sodium iodide;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja00060a083
