diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate

Base Information

• Chemical Name: diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate
• CAS No.: 1011258-60-8
• Molecular Formula: C₂₁H₃₇NO₈P₂
• Molecular Weight: 493.474
• Mol file: 1011258-60-8.mol

Synonyms:diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate

Chemical Property of diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate

There total 1 articles about diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Tetraethyl methylenediphosphonate (1660-94-2) + N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide (271600-36-3) → diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate (1011258-60-8)

Guidance literature:

Tetraethyl methylenediphosphonate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide; In tetrahydrofuran; at -20 - -10 ℃; for 3.5h; Further stages.;

DOI:10.1016/j.tet.2007.11.072

Reference yield: 100.0%

diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate (1011258-60-8) → diethyl [2-amino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate hydrochloride (1011258-65-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.11.072

Reference yield: 78.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate (1011258-60-8) → diethyl [1-(tert-butoxycarbonylamino-phenylmethyl)vinyl]phosphonate (1011258-78-8)

Guidance literature:

diethyl [2-tert-butoxycarbonylamino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate; With potassium tert-butylate; In tetrahydrofuran; at -10 ℃; for 0.166667h;

formaldehyd; In tetrahydrofuran; at -10 ℃; for 5h; Further stages.;

DOI:10.1016/j.tet.2007.11.072

upstream raw materials:

Tetraethyl methylenediphosphonate

N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide

Downstream raw materials:

diethyl [2-amino-1-(diethoxyphosphoryl)-2-phenylethyl]phosphonate hydrochloride

(2-amino-2-phenyl-1-phosphonoethyl)phosphonic acid hydrochloride

diethyl (E)-(2-phenylethenyl)phosphonate

diethyl N-tert-butyloxycarbonylphosphoramidate