2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

Base Information

Chemical Name:2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide
CAS No.:577795-08-5
Molecular Formula:C₂₅H₃₇N₅O
Molecular Weight:423.602
Hs Code.:

Synonyms:2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

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Chemical Property of 2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

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Technology Process of 2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

There total 5 articles about 2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 577795-03-0
N,N-diisopropyl-2-[6-(4-isopropylpiperazin-1-yl)-3-nitropyridin-2-yl]benzamide

: 577795-08-5
2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 1551.44 Torr;
DOI:10.1021/jm030109s

Reference yield:

: 4318-42-7
1-(1-methylethyl)piperazine

: 577795-08-5
2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / ethyldiisopropylamine / tetrahydrofuran / 65 °C

2: 98 percent / H₂ / Pd/C / methanol / 2 h / 1551.44 Torr

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm030109s

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 577795-08-5
2-[3-amino-6-(4-isopropylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / K₂CO₃; [Pd(PPh₃)4] / toluene; ethanol; H₂O / 80 °C

2: 83 percent / ethyldiisopropylamine / tetrahydrofuran / 65 °C

3: 98 percent / H₂ / Pd/C / methanol / 2 h / 1551.44 Torr

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1021/jm030109s