1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

Base Information

Chemical Name:1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole
CAS No.:189268-93-7
Molecular Formula:C₄₄H₄₂Cl₂N₄O₃Si
Molecular Weight:773.834
Hs Code.:

Synonyms:1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

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Chemical Property of 1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

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Technology Process of 1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

There total 7 articles about 1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 189268-17-5
(E)-4-[N-(2-pyridylmethyl)carbamoyl]cinnamic acid

: 189268-27-7
2-aminomethyl-1-[3-(tert-butyldiphenylsilyloxymethyl)-2,4-dichlorophenyl]pyrrole

: 189268-93-7
1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

Guidance literature:: With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm030159x

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 189268-93-7
1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 79.7 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 4 h

2: 77.3 percent / aq. NaOH / methanol / 2 h / 60 °C

3: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

With sodium hydroxide; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x

Reference yield:

: 115974-97-5
methyl (E)-4-carboxyl cinnamate

: 189268-93-7
1-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-2-[4-[N-(pyridin-2-ylmethyl)carbamoyl]-cinnamoylaminomethyl]pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 79.7 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 4 h

2: 77.3 percent / aq. NaOH / methanol / 2 h / 60 °C

3: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

With sodium hydroxide; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x