Boc-Phe-MeβAla-OBzl

Base Information

• Chemical Name: Boc-Phe-MeβAla-OBzl
• CAS No.: 188687-69-6
• Molecular Formula: C₂₅H₃₂N₂O₅
• Molecular Weight: 440.539
• Mol file: 188687-69-6.mol

Synonyms:Boc-Phe-MeβAla-OBzl

Chemical Property of Boc-Phe-MeβAla-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Phe-MeβAla-OBzl

There total 1 articles about Boc-Phe-MeβAla-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + benzyl N-methyl-4-aminobutanoate p-toluenesulfonate → Boc-Phe-MeβAla-OBzl (188687-69-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethyl acetate; at -10 - 20 ℃;

DOI:10.1021/jm010357t

Reference yield:

Boc-Phe-MeβAla-OBzl (188687-69-6) → 3-[((S)-2-Amino-3-phenyl-propionyl)-methyl-amino]-propionic acid benzyl ester

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h;

DOI:10.1021/jm010357t

Reference yield:

Boc-Phe-MeβAla-OBzl (188687-69-6) → D-Arg(Cbz2)-Phe-MeβAla-OBzl

Guidance literature:

Multi-step reaction with 3 steps

1: 4 N HCl / ethyl acetate / 0.5 h / 20 °C

2: 11.7 g / HOBt; WSCI*HCl; Et₃N / dimethylformamide / -10 - 4 °C

3: 100 percent / 4 N HCl / ethyl acetate / 0.42 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm010357t

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

Boc-D-Arg(Cbz2)-Phe-MeβAla-OBzl