5-fluoro-2,3-diphenylbenzofuran

Base Information

• Chemical Name: 5-fluoro-2,3-diphenylbenzofuran
• CAS No.: 1446486-46-9
• Molecular Formula: C₂₀H₁₃FO
• Molecular Weight: 288.321
• Mol file: 1446486-46-9.mol

Synonyms:5-fluoro-2,3-diphenylbenzofuran

Chemical Property of 5-fluoro-2,3-diphenylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-fluoro-2,3-diphenylbenzofuran

There total 5 articles about 5-fluoro-2,3-diphenylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-fluoro-N-phenoxy)acetamide (1443440-59-2) + diphenyl acetylene (501-65-5) → 5-fluoro-2,3-diphenylbenzofuran (1446486-46-9)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201300881

Reference yield: 85.0%

4-Fluorophenol (371-41-5) + diphenyl acetylene (501-65-5) → 5-fluoro-2,3-diphenylbenzofuran (1446486-46-9)

Guidance literature:

With oxygen; copper(II) bis(trifluoromethanesulfonate); zinc(II) chloride; In nitrobenzene; at 120 ℃; for 24h; Schlenk technique;

DOI:10.1039/c3cc42326c

Reference yield:

2-(4-fluorophenoxy)isoindoline-1,3-dione (880473-80-3) → 5-fluoro-2,3-diphenylbenzofuran (1446486-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol; chloroform / 20 °C

2: sodium carbonate / ethyl acetate; water / 2 h / 0 °C

3: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid / dichloromethane / 20 °C

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; sodium carbonate; hydrazine hydrate; acetic acid; In methanol; dichloromethane; chloroform; water; ethyl acetate;

DOI:10.1002/anie.201300881

upstream raw materials:

4-Fluorophenol

diphenyl acetylene

2-(4-fluorophenoxy)isoindoline-1,3-dione

(4-fluoro-N-phenoxy)acetamide