N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine

Base Information

• Chemical Name: N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine
• CAS No.: 81282-28-2
• Molecular Formula: C₂₁H₂₇N₇OS
• Molecular Weight: 425.558

Synonyms:N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine

Chemical Property of N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine

Chemical Property:

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Technology Process of N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine

There total 4 articles about N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-[6,7,8,9-Tetrahydro-imidazo[1,5-c][1,3]diazepin-(5Z)-ylidene]-benzamide (97043-66-8) + 4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole (38585-67-0) → N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine (81282-28-2)

Guidance literature:

In ethanol; for 20h; Heating;

DOI:10.1021/jm00148a007

Reference yield:

3-[imidazol-4(5)-yl]propylamine (40546-33-6) → N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine (81282-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / CH₂Cl₂; ethanol / 0.5 h / Ambient temperature

2: 65 percent / NaH / dimethylformamide

3: 89 percent / ethanol / 20 h / Heating

With sodium hydride; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00148a007

Reference yield:

N-diphenoxymethylene benzamide (81282-38-4) → N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine (81282-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / CH₂Cl₂; ethanol / 0.5 h / Ambient temperature

2: 65 percent / NaH / dimethylformamide

3: 89 percent / ethanol / 20 h / Heating

With sodium hydride; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00148a007

upstream raw materials:

N-[6,7,8,9-Tetrahydro-imidazo[1,5-c][1,3]diazepin-(5Z)-ylidene]-benzamide

4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole

3-[imidazol-4⁽⁵⁾-yl]propylamine

N-diphenoxymethylene benzamide

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