1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester

Base Information

• Chemical Name: 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester
• CAS No.: 85147-17-7
• Molecular Formula: C₁₅H₂₀N₄O₂
• Molecular Weight: 288.349
• Mol file: 85147-17-7.mol

Synonyms:1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester

Chemical Property of 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester

There total 3 articles about 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(2-Cyano-4-nitrophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester (85147-16-6) → 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester (85147-17-7)

Guidance literature:

With hydrogen; nickel; In ethyl acetate; Ambient temperature;

DOI:10.1002/hlca.19820650719

Reference yield:

2-fluoro-5-nitrobenzonitrile (17417-09-3) → 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester (85147-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / N-ethyldiisopropylamine, N-methyl-2-pyrrolidone / 4.5 h / 90 °C

2: 96 percent / H₂ / Raney-Ni / ethyl acetate / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogen; N-ethyl-N,N-diisopropylamine; nickel; In ethyl acetate;

DOI:10.1002/hlca.19820650719

Reference yield:

4-Methyl-2-piperazincarbonsaeure-aethylester (63285-60-9) → 1-(4-Amino-2-cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester (85147-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / N-ethyldiisopropylamine, N-methyl-2-pyrrolidone / 4.5 h / 90 °C

2: 96 percent / H₂ / Raney-Ni / ethyl acetate / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogen; N-ethyl-N,N-diisopropylamine; nickel; In ethyl acetate;

DOI:10.1002/hlca.19820650719

upstream raw materials:

1-(2-Cyano-4-nitrophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester

2-fluoro-5-nitrobenzonitrile

4-Methyl-2-piperazincarbonsaeure-aethylester

Downstream raw materials:

1-(2-Cyanophenyl)-4-methyl-2-piperazincarbonsaeure-aethylester