(R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal

Base Information

• Chemical Name: (R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal
• CAS No.: 484638-53-1
• Molecular Formula: C₂₁H₂₂BrNO₂
• Molecular Weight: 400.315
• Mol file: 484638-53-1.mol

Synonyms:(R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal

Chemical Property of (R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal

There total 2 articles about (R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

dichloro-acetic acid (79-43-6) + trans-Crotonaldehyde (123-73-9,4170-30-3) + (2S,5S)-5-benzyl-2-(tert-butyl)-3-methylimidazolidin-4-one (346440-54-8,390766-89-9) + 1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indole → (R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal (484638-53-1)

Guidance literature:

In dichloromethane; isopropyl alcohol;

Reference yield:

trans-Crotonaldehyde (123-73-9,4170-30-3) + 1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indole → (R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal (484638-53-1) + (S)-3-[1-(4-bromo-benzyl)-5-methyl-1H-indol-3-yl]-butanal

Guidance literature:

1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indole; With dichloro-acetic acid; (2S,5S)-5-benzyl-2-(tert-butyl)-3-methylimidazolidin-4-one; In dichloromethane; isopropyl alcohol; at 20 ℃;

trans-Crotonaldehyde; In dichloromethane; isopropyl alcohol; at -70 ℃; for 9h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ja017255c

Reference yield: 97.0%

(R)-3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butanal (484638-53-1) → 3-[1-(4-bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-butyric acid

Guidance literature:

With sodium hydroxide; silver nitrate; In ethanol; for 0.75h;

DOI:10.1021/ja017255c

upstream raw materials:

trans-Crotonaldehyde

dichloro-acetic acid

(2S,5S)-5-benzyl-2-(tert-butyl)-3-methylimidazolidin-4-one