{2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester
CAS No.:106469-82-3
Molecular Formula:C₂₆H₃₉NO₇
Molecular Weight:477.598
Hs Code.:

Synonyms:{2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

There total 3 articles about {2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98062-25-0
tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate

: 106469-82-3
{2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Br₂, K₂CO₃ / CH₂Cl₂ / -78 °C

2: 1) KH, 2) n-BuLi / 1) THF, 25 deg C, 2) THF, -78 deg C, 3) THF, -78 deg C to -30 deg C, 10 h

With n-butyllithium; bromine; potassium hydride; potassium carbonate; In dichloromethane;
DOI:10.1021/ja00237a057

Reference yield:

: 69225-59-8
3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-one

: 106469-82-3
{2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Me₃SiOTf, Et₃N, 2) Pd(II)acetate / 1) CH₂Cl₂, 2) CH₃CN, 25 deg C, 14 h

2: 1) KH, 2) n-BuLi / 1) THF, 25 deg C, 2) THF, -78 deg C, 3) THF, -78 deg C to -30 deg C, 10 h

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; palladium diacetate; potassium hydride; triethylamine;
DOI:10.1021/ja00237a057

Reference yield:

: 106469-81-2
3,3-Dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-one

: 106469-78-7
tert-butyl (2-bromo-4,5-dimethoxyphenethyl)carbamate

: 106469-82-3
{2-[2-(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-7-en-9-yl)-4,5-dimethoxy-phenyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With n-butyllithium; potassium hydride; Yield given. Multistep reaction; 1) THF, 25 deg C, 2) THF, -78 deg C, 3) THF, -78 deg C to -30 deg C, 10 h;
DOI:10.1021/ja00237a057