Technology Process of (2R)-benzoyloxy-3,3-difluoroheptanal
There total 7 articles about (2R)-benzoyloxy-3,3-difluoroheptanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1016/0957-4166(94)80051-0
- Guidance literature:
-
Multi-step reaction with 7 steps
1: (COCl)2, DMSO
2: diethylaminosulfur trifluoride / CH2Cl2
3: 78 percent / 4 N HCl / tetrahydrofuran / 12 h / 20 °C
4: 82 percent / DMAP / CH2Cl2 / 16 h / 20 °C
5: 84 percent / pyridine / CH2Cl2 / 16 h / 20 °C
6: 91 percent / aq. HCl / dioxane / 20 h / 20 °C
7: 90 percent / pyridinium chlorochromate, 4A molecular sieves / CH2Cl2 / 2 h / 20 °C
With
pyridine; hydrogenchloride; dmap; oxalyl dichloride; diethylamino-sulfur trifluoride; 4 A molecular sieve; dimethyl sulfoxide; pyridinium chlorochromate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/0957-4166(94)80051-0
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethylaminosulfur trifluoride / CH2Cl2
2: 78 percent / 4 N HCl / tetrahydrofuran / 12 h / 20 °C
3: 82 percent / DMAP / CH2Cl2 / 16 h / 20 °C
4: 84 percent / pyridine / CH2Cl2 / 16 h / 20 °C
5: 91 percent / aq. HCl / dioxane / 20 h / 20 °C
6: 90 percent / pyridinium chlorochromate, 4A molecular sieves / CH2Cl2 / 2 h / 20 °C
With
pyridine; hydrogenchloride; dmap; diethylamino-sulfur trifluoride; 4 A molecular sieve; pyridinium chlorochromate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/0957-4166(94)80051-0
