ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate

Base Information

• Chemical Name: ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate
• CAS No.: 1586023-61-1
• Molecular Formula: C₂₄H₃₉N₃O₄
• Molecular Weight: 433.591
• Mol file: 1586023-61-1.mol

Synonyms:ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate

Chemical Property of ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate

There total 3 articles about ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-benzylideneisopropylamine N-oxide (10229-64-8,143957-81-7,300802-10-2) + ethyl 2-{[isobutyl(N-isopropylcarbamoyl)amino]methyl}acrylate (1586023-53-1) → ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate (1586023-61-1)

Guidance literature:

In toluene; at 80 ℃; for 24h; regiospecific reaction; Inert atmosphere;

DOI:10.3184/174751913X13783169779948

Reference yield:

ethyl 2-bromomethyl-2-propenoate (17435-72-2) → ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate (1586023-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / chloroform

2: toluene / Inert atmosphere; Reflux

3: toluene / 24 h / 80 °C / Inert atmosphere

With triethylamine; In chloroform; toluene;

DOI:10.3184/174751913X13783169779948

Reference yield:

C10H19NO2 (1586023-50-8) → ethyl 5-{isobutyl[(isopropyl carbamoyl)amino]methyl}-2-isopropyl-3-phenylisoxazolidine-5-carboxylate (1586023-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Inert atmosphere; Reflux

2: toluene / 24 h / 80 °C / Inert atmosphere

In toluene;

DOI:10.3184/174751913X13783169779948

upstream raw materials:

N-benzylideneisopropylamine N-oxide

ethyl 2-{[isobutyl(N-isopropylcarbamoyl)amino]methyl}acrylate

ethyl 2-bromomethyl-2-propenoate

C₁₀H₁₉NO₂

Downstream raw materials:

9-isobutyl-2,7-diisopropyl-3-phenyl-1-oxa-2,7,9-triazaspiro[4.5]decane-6,8-dione