(3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Base Information

Chemical Name:(3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
CAS No.:1194687-32-5
Molecular Formula:C₂₃H₂₉N₅O₃
Molecular Weight:423.515
Hs Code.:

Synonyms:(3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Chemical Property of (3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Technology Process of (3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

There total 4 articles about (3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1194686-95-7
(3aR,6aS)-tert-butyl 5-(6-(methoxycarbonyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 100-46-9
benzylamine

: 1194687-32-5
(3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: (3aR,6aS)-tert-butyl 5-(6-(methoxycarbonyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; With magnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

benzylamine; In tetrahydrofuran; at 40 ℃; for 18h;

Reference yield:

: 6164-79-0
methyl pyrazine-2-carboxylate

: 1194687-32-5
(3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 16 h / 60 °C

2.1: thionyl chloride / 8 h / Reflux

3.1: sodium carbonate / dimethyl sulfoxide / 16 h / 120 °C

4.1: magnesium chloride / tetrahydrofuran / 0.08 h / 20 °C

4.2: 18 h / 40 °C

With thionyl chloride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; magnesium chloride; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm201045m

Reference yield:

: 23611-75-8
6-chloro-pyrazine-2-carboxylic acid methyl ester

: 1194687-32-5
(3aR,6aS)-tert-butyl 5-(6-(benzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / dimethyl sulfoxide / 16 h / 120 °C

2.1: magnesium chloride / tetrahydrofuran / 0.08 h / 20 °C

2.2: 18 h / 40 °C

With sodium carbonate; magnesium chloride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm201045m