(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

Base Information

Chemical Name:(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt
CAS No.:1231755-51-3
Molecular Formula:C₁₂H₂₃N*C₂₂H₂₂N₂O₄
Molecular Weight:559.749
Hs Code.:

Synonyms:(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

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Chemical Property of (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

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Technology Process of (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

There total 6 articles about (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178306-52-0,178306-49-5
(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid

: 1231755-51-3
(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / 0.33 h / 25 - 35 °C

1.2: 24 h / 40 - 45 °C

2.1: ethyl acetate / 0.75 h / 25 - 30 °C

With sodium hydroxide; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 177036-94-1
ambrisentan

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 1231755-51-3
(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

Guidance literature:: In ethyl acetate; at 25 - 30 ℃; for 0.75h;

Reference yield:

: 177036-78-1
(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester

: 1231755-51-3
(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 25 - 35 °C

1.2: 4 h / 90 - 95 °C

2.1: sodium hydroxide; water / 1,4-dioxane / 3 h / 25 - 90 °C

2.2: 25 - 35 °C / pH 1.8

3.1: ethyl acetate / 0.75 h / 25 - 30 °C

With water; potassium carbonate; sodium hydroxide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;