1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
CAS No.:119794-49-9
Molecular Formula:C₁₅H₂₄N₂O₄Si
Molecular Weight:324.452
Hs Code.:

Synonyms:1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

There total 1 articles about 1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 120673-69-0
1-<5-O-tert-Butyldimethylsilyl-2,3-O-bis(methylsulfonyl)-β-D-ribofuranosyl>uracil

: 234449-42-4
bis-(4-perfluorohexylphenyl) diselenide

: 119794-49-9
1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1-[(2R,5R)-5-Hydroxymethyl-4-(4-tridecafluorohexyl-phenylselanyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; Heating;
DOI:10.1021/ol0066532

Reference yield:

: 119794-49-9
1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1-((2R,5S)-5-Triphenylsilanyloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / TBAF / tetrahydrofuran / 20 °C

2: pyridine / 0 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jm050111e

Reference yield:

: 119794-49-9
1-((2R,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 132364-17-1
1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl]uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / TBAF / tetrahydrofuran / 20 °C

2: 73 percent / imidazole / dimethylformamide / 18 h / 0 - 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050111e