Cbz-(R)-3-pyrrolidinesulfonyl chloride

Base Information

• Chemical Name: Cbz-(R)-3-pyrrolidinesulfonyl chloride
• CAS No.: 1134112-00-7
• Molecular Formula: C₁₂H₁₄ClNO₄S
• Molecular Weight: 303.766

Synonyms:Cbz-(R)-3-pyrrolidinesulfonyl chloride

Chemical Property of Cbz-(R)-3-pyrrolidinesulfonyl chloride

Chemical Property:

• Boiling Point: 442.6±44.0 °C(Predicted)
• Density: 1.43±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

benzyl(3R)-3-(chlorosulfonyl)pyrrolidine-1-carboxylate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3R)-3-(Chlorosulfonyl)-phenylmethyl Ester 1-Pyrrolidinecarboxylic Acid is used as a reactant in the synthesis and opioid receptor-binding structure-activity relationship of endomorphin and morphiceptin analogs.

Technology Process of Cbz-(R)-3-pyrrolidinesulfonyl chloride

There total 2 articles about Cbz-(R)-3-pyrrolidinesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17NO3S (1134111-98-0) → Cbz-(R)-3-pyrrolidinesulfonyl chloride (1134112-00-7)

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; In water; acetonitrile; at 0 ℃; for 1h;

Reference yield:

C12H14NO5S(1-)*Na(1+) → Cbz-(R)-3-pyrrolidinesulfonyl chloride (1134112-00-7)

Guidance literature:

With phosgene; N,N-dimethyl-formamide; In dichloromethane; toluene; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.07.022

Reference yield: 52.0%

Cbz-(R)-3-pyrrolidinesulfonyl chloride (1134112-00-7) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → Cbz-(R)-βPrs-Phe-OMe (1251071-44-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2010.07.022

upstream raw materials:

C₁₄H₁₇NO₃S

Downstream raw materials:

C₃₁H₄₂N₆O₇S

Cbz-(R)-βPrs-Phe-OMe

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