2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Base Information

Chemical Name:2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride
CAS No.:1262859-01-7
Molecular Formula:C₉H₉BrF₃NO*ClH
Molecular Weight:320.537
Hs Code.:

Synonyms:2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

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Chemical Property of 2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Chemical Property:

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Technology Process of 2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

There total 4 articles about 2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262860-80-9
[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

: 1262859-01-7
2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 1262858-99-0
C₁₃H₁₃BrF₃NO₂

: 1262859-01-7
2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / -70 - 0 °C

1.2: 0 °C

2.1: sodium hydrogencarbonate; ozone / dichloromethane; methanol / -78 °C

2.2: 0.67 h / -78 - 0 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; ozone; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1262858-98-9
rac-tert-butyl [1-(5-bromo-2-fluorophenyl)-1-(difluoromethyl)prop-2-en-1-yl]carbamate

: 1262859-01-7
2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; ozone / dichloromethane; methanol / -78 °C

1.2: 0.67 h / -78 - 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; ozone; In 1,4-dioxane; methanol; dichloromethane;