Chemical Property of Fluoroclebopride
Chemical Property:
- Vapor Pressure:7.68E-11mmHg at 25°C
- Boiling Point:518.2°Cat760mmHg
- PKA:13.62±0.20(Predicted)
- Flash Point:267.2°C
- PSA：71.08000
- Density:1.31g/cm3
- LogP:4.55820
- XLogP3:3.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:391.1462828
- Heavy Atom Count:27
- Complexity:482
- Purity/Quality:
-
97% *data from raw suppliers
Fluoroclebopride >98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=CC(=C(C=C1C(=O)NC2CCN(CC2)CC3=CC=C(C=C3)F)Cl)N
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Description
Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1, serotonin 5-HT2, and α2-adrenergic receptors (Kis = >10,000, 283, and 1,300 nM, respectively). A fluorine-18 moiety has been used to label 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide for use as a probe for studying D2/D3 receptor availability via PET in various monkey models.
