trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Base Information

Chemical Name:trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane
CAS No.:267402-72-2
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:

Synonyms:trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Suppliers and Price of trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

There total 7 articles about trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 21615-34-9
2-Methoxybenzoyl chloride

: 603138-40-5
4-aminomethyl-4-phenyl-cyclohexanol

: 267402-72-2
trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Guidance literature:: With triethylamine; at 20 ℃;
DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

: 25115-74-6
4-cyano-4-phenylcyclohexanone

: 267402-72-2
trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / NaBH₄ / tetrahydrofuran / -78 °C

2: LiAlH₄ / tetrahydrofuran / Heating

3: 70 percent / Et₃N

4: 72 percent / PPh₃; DEAD

5: MeOH; NaOMe / tetrahydrofuran / 20 °C

6: HCl

7: 99 percent / Et₃N / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium methylate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 4: Mitsunobu reaction;
DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

: 38289-22-4
cis-4-hydroxy-1-phenylcyclohexanecarbonitrile

: 267402-72-2
trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: 70 percent / Et₃N

3: 72 percent / PPh₃; DEAD

4: MeOH; NaOMe / tetrahydrofuran / 20 °C

5: HCl

6: 99 percent / Et₃N / 20 °C

With hydrogenchloride; methanol; lithium aluminium tetrahydride; sodium methylate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 3: Mitsunobu reaction;
DOI:10.1016/S0960-894X(03)00014-3