methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate

Base Information

Chemical Name:methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate
CAS No.:146406-46-4
Molecular Formula:C₃₁H₄₃N₂O₁₀P
Molecular Weight:634.664
Hs Code.:

Synonyms:methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate

Suppliers and Price of methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate

There total 5 articles about methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 14684-31-2
methyl hypophosphite

: 113850-76-3,210962-91-7
(R)-2-((tert-butoxycarbonyl)amino)-3-(4-iodophenyl)propanoate

: 146406-46-4
methyl bis(4-<2-(tert-butoxycarbonylamino)-2-(methyloxycarbonyl)ethyl>phenyl)phosphinate

Guidance literature:: With triethylamine; triphenylphosphine; palladium diacetate; In acetonitrile; at 77 ℃; for 4h;
DOI:10.1055/s-1992-26352

Reference yield: 59.0%

: 14684-31-2
methyl hypophosphite

: 113850-76-3,210962-91-7
N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester

: 146406-46-4
(S)-2-tert-Butoxycarbonylamino-3-(4-{[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-methoxy-phosphinoyl}-phenyl)-propionic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; methyloxirane;
DOI:10.1021/ja00045a062

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 146406-46-4
(S)-2-tert-Butoxycarbonylamino-3-(4-{[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-methoxy-phosphinoyl}-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: I₂, NaIO₃, H₂SO₄ / acetic acid

2: SOCl₂

4: 59 percent / 1-methyloxirane, (Ph₃P)2PdCl₂

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; sodium iodate; sulfuric acid; iodine; methyloxirane; In acetic acid;
DOI:10.1021/ja00045a062