1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione
• CAS No.: 198965-11-6
• Molecular Formula: C₃₃H₃₃N₃O₈
• Molecular Weight: 599.64
• Mol file: 198965-11-6.mol

Synonyms:1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione

Chemical Property of 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione

There total 3 articles about 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil (173170-12-2) + ethyl isocyanate (109-90-0) → 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione (198965-11-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Heating;

DOI:10.1080/07328319708006140

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione (198965-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / pyridine / 16 h / Ambient temperature

2: 90 percent / NaH / tetrahydrofuran / Heating

With dmap; sodium hydride; In tetrahydrofuran; pyridine;

DOI:10.1080/07328319708006140

Reference yield:

2,2'-Anhydrouridine (3736-77-4) → 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethyl-2-oxo-hexahydro-furo[3,4-d]oxazol-4-yl}-1H-pyrimidine-2,4-dione (198965-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / pyridine / 16 h / Ambient temperature

2: 90 percent / NaH / tetrahydrofuran / Heating

With dmap; sodium hydride; In tetrahydrofuran; pyridine;

DOI:10.1080/07328319708006140

upstream raw materials:

2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil

ethyl isocyanate

4,4'-dimethoxytrityl chloride

2,2'-Anhydrouridine

Downstream raw materials:

1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-ethylamino-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione