1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid

Base Information

• Chemical Name: 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid
• CAS No.: 1272718-04-3
• Molecular Formula: C₁₈H₁₇BF₃NO₄S
• Molecular Weight: 411.209
• Mol file: 1272718-04-3.mol

Synonyms:1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid

Chemical Property of 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid

There total 3 articles about 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Triisopropyl borate (5419-55-6) + 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole (1272718-01-0) → 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid (1272718-04-3)

Guidance literature:

1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.333333h;

Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 18h;

With water; In tetrahydrofuran; hexane;

Reference yield:

4-isopropylbenzenesulfonyl chloride (54997-90-9) → 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid (1272718-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - 20 °C

2.2: 18 h / -78 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil;

Reference yield:

5-trifluoromethyl-1H-indole (100846-24-0) → 1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole-2-boronic acid (1272718-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - 20 °C

2.2: 18 h / -78 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil;

upstream raw materials:

4-isopropylbenzenesulfonyl chloride

5-trifluoromethyl-1H-indole

Triisopropyl borate

1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indole

Downstream raw materials:

2-fluoro-4-[[1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indol-2-yl]methyl]benzoic acid, methyl ester

2-fluoro-4-[[1-[[4-(1-methylethyl)phenyl]sulfonyl]-5-(trifluoromethyl)-1H-indol-2-yl]methyl]benzoic acid