2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

Base Information

• Chemical Name: 2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane
• CAS No.: 98634-98-1
• Molecular Formula: C₁₈H₂₆O₆
• Molecular Weight: 338.401
• Mol file: 98634-98-1.mol

Synonyms:2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

Chemical Property of 2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

There total 1 articles about 2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-bis((2-methoxyethoxy)methoxy)benzaldehyde (79834-12-1) + 4,4-ethylenedioxypentyl triphenyl phosphonium bromide → 2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane (98634-98-1) + 2-[(Z)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

Guidance literature:

With lithium diisopropyl amide; Yield given; 1.) THF, 0 deg C, 2.) THF, a) -78 deg C, 30 min, b) from -40 to -30 deg C, 1 h;

DOI:10.1021/jo00225a098

Reference yield: 75.0%

2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane (98634-98-1) → 2-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butyraldehyde (119384-73-5)

Guidance literature:

With iodine; silver(l) oxide; In 1,4-dioxane; water; at 0 ℃;

DOI:10.1039/C39880000726

Reference yield:

2-[(E)-4-(2,6-Bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane (98634-98-1) → [(Z)-1-(2,6-Bis-methoxymethoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-propenyloxy]-triisopropyl-silane

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / I₂, Ag₂O / dioxane; H₂O / 0 °C

2: 5 percent / NEt₃ / tetrahydrofuran / 0 °C

With iodine; triethylamine; silver(l) oxide; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1039/C39880000726

upstream raw materials:

2,6-bis((2-methoxyethoxy)methoxy)benzaldehyde

Downstream raw materials:

2-[(E)-4-(3-Bromo-2,6-bis-methoxymethoxy-phenyl)-but-3-enyl]-2-methyl-[1,3]dioxolane

2-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butyraldehyde