Chemical Property of Sulopenem
Chemical Property:
- Vapor Pressure:3.2E-22mmHg at 25°C
- Boiling Point:693.1°Cat760mmHg
- PKA:3.88±0.40(Predicted)
- Flash Point:373°C
- PSA：164.72000
- Density:1.74g/cm3
- LogP:1.21000
- XLogP3:0
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:4
- Exact Mass:349.01123610
- Heavy Atom Count:21
- Complexity:563
- Purity/Quality:
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Sulopenem *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C1C2N(C1=O)C(=C(S2)SC3CCS(=O)C3)C(=O)O)O
- Isomeric SMILES:C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(S2)S[C@H]3CC[S@@](=O)C3)C(=O)O)O
- Recent ClinicalTrials:Safety, Tolerability, and Pharmacokinetics of Sulopenem in Adolescents
- Recent EU Clinical Trials:A prospective, Phase 3, randomized, multi-center, double-blind, double dummy study of the efficacy, tolerability and safety of intravenous sulopenem followed by oral sulopenem-etzadroxil with probenecid versus intravenous ertapenem followed by oral ciprofloxacin or amoxicillin-clavulanate for treatment of complicated urinary tract infections in adults.
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Description
Sulopenem is a parenteral penem that demonstrates high activity against Gram-positive, Gram-negative, and anaerobic bacteria. Since it is stable in relation to renal dehydropeptidase I, it does not require concomitant administration of an inhibitor of this enzyme.
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Uses
Antibacterial. Sulopenem is a β-Lactamase inhibitor which is used in treatment of microbial infections. It is an important reagent for many drugs synthesized against bacterial infections.
