(E)-3-(3-methoxy-4-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]prop-2-enamide

Base Information

Chemical Name:(E)-3-(3-methoxy-4-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]prop-2-enamide
CAS No.:56113-94-1
Molecular Formula:C₃₃H₃₃NO₅
Molecular Weight:523.629
Hs Code.:
NSC Number:249186
DSSTox Substance ID:DTXSID80421315
Wikidata:Q82232765

Synonyms:NSC249186;56113-94-1;SCHEMBL17821711;SCHEMBL17821714;DTXSID80421315;NSC-249186

Suppliers and Price of (E)-3-(3-methoxy-4-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (E)-3-(3-methoxy-4-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]prop-2-enamide

Chemical Property:

Vapor Pressure:1.7E-21mmHg at 25°C
Boiling Point:735.5°C at 760 mmHg
Flash Point:398.6°C
Density:1.17g/cm³
XLogP3:5.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:13
Exact Mass:523.23587315
Heavy Atom Count:39
Complexity:717

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)CCNC(=O)C=CC2=CC(=C(C=C2)OCC3=CC=CC=C3)OC)OCC4=CC=CC=C4
Isomeric SMILES:COC1=C(C=CC(=C1)CCNC(=O)/C=C/C2=CC(=C(C=C2)OCC3=CC=CC=C3)OC)OCC4=CC=CC=C4

Technology Process of (E)-3-(3-methoxy-4-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]prop-2-enamide

There total 3 articles about (E)-3-(3-methoxy-4-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 77795-22-3
4-benzyloxy-3-methoxycinnamic acid

: 91408-57-0,56113-94-1
N-<2-(4-benzyloxy-3-methoxyphenyl)ethyl>-4'-benzyloxy-3'-methoxycinnamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 91408-57-0,56113-94-1
N-<2-(4-benzyloxy-3-methoxyphenyl)ethyl>-4'-benzyloxy-3'-methoxycinnamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; piperidine / 6 h / 85 - 115 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With piperidine; pyridine; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; 1: |Knoevenagel Condensation;

Reference yield:

: 63909-38-6
1-(benzyloxy)-2-methoxy-4-[(E)-2-nitroethenyl]benzene

: 91408-57-0,56113-94-1
N-<2-(4-benzyloxy-3-methoxyphenyl)ethyl>-4'-benzyloxy-3'-methoxycinnamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / Inert atmosphere; Reflux

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;